Inhibition of Influenza Entry by Organosilicon Compounds.

ABSTRACT: Hemagglutinin (HA) plays a critical role in the entry of influenza and thus HA is a target for the development of entry inhibitors as antivirals. One of the first small molecule inhibitors of influenza entry to be described was tert-butylhydroquinone (TBHQ), a commonly used antioxidant. This compound was shown to inhibit influenza containing Group 2 HA, such as H3 and H7 HA circulating in humans and avians. One limitation of TBHQ is the propensity to oxidize in solution, resulting in a less active form of the compound. Recently, our group has shown that the reactivity of TBHQ may be significantly reduced through substitution of one hydroxyl group with a methoxy, resulting in a concurrent increase in potency and a decrease in cytotoxicity. In this study, we demonstrate that the inhibitory c

SUBMITTER: Antanasijevic A 

PROVIDER: S-EPMC12150666 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature