Efficacy and safety of larotrectinib as first-line treatment for patients with TRK fusion cancer.

ABSTRACT:

Background

Larotrectinib is a first-in-class, highly selective tropomyosin receptor kinase (TRK) inhibitor approved for tumour-agnostic use in patients with TRK fusion cancer. Data on treatment-naïve adult and paediatric patients or the subset of treatment-naïve paediatric patients who discontinued larotrectinib after surgery or achieving durable clinical benefit are unknown.

Materials and methods

Patients with treatment-naïve (no prior systemic therapy) metastatic/unresectable TRK fusion cancer from three larotrectinib clinical trials [NCT02122913, NCT02637687 (SCOUT) and NCT02576431 (NAVIGATE)] were included. Responses were assessed by an independent review committee (RECIST v1.1). SCOUT-enrolled patients could electively discontinue larotrectinib after surgical resection

SUBMITTER: Hong DS 

PROVIDER: S-EPMC12151180 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature