Cross-tissue coordination between SLC nucleoside transporters regulates reproduction in Caenorhabditis elegans.

ABSTRACT: Metabolism is fundamental to organism physiology and pathology. From the intricate network of metabolic reactions, diverse chemical molecules, collectively termed metabolites, are produced. In multicellular organisms, metabolite communication between different tissues is vital for maintaining homeostasis and adaptation. However, the molecular mechanisms mediating these metabolite communications remain poorly understood. Here, we focus on nucleosides and nucleotides, essential metabolites involved in multiple cellular processes, and report the pivotal role of the SLC29A family of transporters in mediating nucleoside coordination between the soma and the germline. Through genetic analysis, we discovered that two Caenorhabditis elegans homologs of SLC29A transporters, Equilibrative Nucleoside

SUBMITTER: Guan Y 

PROVIDER: S-EPMC12151481 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature