Changes in metabolism-related RNA expression in circulating white blood cells of aged individual with physical frailty.

ABSTRACT:

Background

Physical frailty is an age-related clinical condition associated with deterioration of physiological capacity. In aged mice, increased RNA expression of metabolism-related genes in circulating white blood cells (WBC) correlates with impaired physical function.

Methods

Twenty elderly volunteers were enrolled in this exploratory analysis and the possible link between RNA expression of metabolism-related genes in WBC and impairment of their physical function was investigated (jRCT1050210166. Feb. 02, 2022). In mechanism of action studies, cellular interactions between WBC and cells in muscle tissue were investigated in mice.

Results

RNA expression of metabolism-related genes, such as glucose transporter 1 (Glut1), Glut3, AMP-activated protein kinase A, and pro

SUBMITTER: Okinaka Y 

PROVIDER: S-EPMC12151501 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature