Developmental onset of planarian whole-body regeneration depends on axis reset.

ABSTRACT: Regenerative abilities vary across species and developmental stages of animal life cycles. Determining mechanisms that promote or limit regeneration in certain life cycle stages may pinpoint the most critical factors for successful regeneration and suggest strategies for reverse-engineering regenerative responses in therapeutic settings. In contrast to many mammalian systems, which typically show a loss of regenerative abilities with age, planarian flatworms remain highly regenerative throughout adulthood. The robust reproductive and regenerative capabilities of the planarian Schmidtea polychroa (S. polychroa) make them an ideal model to determine when and how regeneration competence is established during development. We report that S. polychroa gradually acquires whole-body regenerative a

SUBMITTER: Booth CLT 

PROVIDER: S-EPMC12151775 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature