Feasibility of axicabtagene ciloleucel in the outpatient setting: primary analysis of prospective trial.

ABSTRACT: The pivotal trials of axicabtagene ciloleucel (axi-cel) chimeric Antigen receptor (CAR-T) therapy and other CD19 CAR-Ts were mainly done in the inpatient setting. We conducted a single-center non-randomized open label prospective clinical trial (NCT05108805). Objective was to evaluate the feasibility and safety of outpatient administration of axi-cel for relapsed/refractory diffuse B cell lymphoma (R/R DLBCL) using continuous remote patient monitoring with wearable devices and telemedicine. We enrolled 25 and treated 20 patients on this clinical trial from November 2021 to October 2023. The median follow up was 374 days (95% CI: 364-484). The median age was 69 years and 18 of 20 patients (90%) received prophylactic corticosteroids. Nineteen patients got admitted for management of cytokine

SUBMITTER: Dholaria B 

PROVIDER: S-EPMC12151859 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature