Deciphering the Contribution of Circular RNAs to Age-Related Decline in Sertoli Cell Survivor.

ABSTRACT: Male fertility declines during aging. This process mainly affects spermatogonia and Sertoli cells, leading to impaired spermatogenesis and poor-quality sperm production. Circular RNAs (circRNAs) are covalently closed RNA molecules produced by backsplicing. In the field of male reproduction, circRNAs boast great potential in the regulation of spermatogenesis and sperm morpho-functional skills. However, their potential role in age-related male reproductive anomalies remains largely elusive. Here, we analyzed the reproductive phenotype of the aged male mouse experimental model, pointing our attention to a putative functional link between circRNAs and Sertoli cell survival. Our results confirm several testicular age-related defects including: (i) altered morphology of the seminiferous epitheli

SUBMITTER: Manfrevola F 

PROVIDER: S-EPMC12151912 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature