TCF19 expression and significance analysis in breast cancer: integrated bioinformatics analysis and histological validation.

ABSTRACT:

Background

Transcription factor 19 (TCF19) is an important member of the transcription factor family, but its role in cancer is not well understood. This study aims to clarify the function of TCF19 and explore its mechanisms across various cancers, with a specific focus on breast cancer, using bioinformatics analysis and histological validation.

Methods

Gene expression profiles and clinical data were obtained from sources like The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Genotype-Tissue Expression (GTEx) for bioinformatics analysis. Tumor-immune interactions were studied using the TISIDB database for immune-related insights. To confirm these findings, TCF19 expression was measured using quantitative RT-PCR, immunohistochemistry (IHC), and western blot a

SUBMITTER: Yu H 

PROVIDER: S-EPMC12151946 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature