Histotripsy: A novel non-invasive ultrasound technology for precision thrombolysis in acute ischemic stroke management.

ABSTRACT: BackgroundStroke remains a major cause of morbidity and mortality worldwide. Traditional treatments for ischemic stroke such as mechanical thrombectomy and pharmacological thrombolysis are often less effective or inaccessible for certain patient populations, particularly those with delayed hospital arrival, contraindications to thrombolytics, or in regions with limited access to endovascular care. This study investigates the feasibility of using histotripsy, a non-invasive ultrasound technology, to precisely liquefy thrombi in an artificial experimental setup.MethodsClot analogs were introduced into sample tubes, and focused ultrasound was applied using optimized parameters, including pulses per burst, repetition rates, and output amplitudes. These parameters were systematically adjusted t

SUBMITTER: Hassan AE 

PROVIDER: S-EPMC12151993 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature