Association of Alzheimer's Disease Polygenic Risk Score with Concussion Severity and Recovery Metrics.

ABSTRACT:

Background

Identification of genetic alleles associated with both Alzheimer's disease (AD) and concussion severity/recovery could help explain the association between concussion and elevated dementia risk. However, there has been little investigation into whether AD risk genes associate with concussion severity/recovery, and the limited findings are mixed.

Objective

We used AD polygenic risk scores (PRS) and APOE genotypes to investigate any such associations in the NCAA-DoD Grand Alliance CARE Consortium (CARE) dataset.

Methods

We assessed six concussion outcomes in 931 participants, including two recovery measures (number of days to asymptomatic and to return to play (RTP)) and four severity measures (scores on SAC and BESS, SCAT symptom severity and total number of

SUBMITTER: Dybing KM 

PROVIDER: S-EPMC12152024 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature