Development and validation of a nomogram risk prediction model for PICC-related thrombosis in children with hematological malignancies.

ABSTRACT: Early identification of high-risk patients is crucial for preventing peripherally intravenous central catheter (PICC)-related thrombosis in children with hematological malignancies. This study aims to develop and validate a clinical risk prediction tool for PICC-related thrombosis. A retrospective analysis was conducted on 519 children with hematological malignancies who underwent PICC catheterization at Tongji Hospital between January 2018 and December 2023. Among these children, 98 (18.9%) developed PICC-related thrombosis. A total of 54 potential predictor variables were analyzed, and six independent risk factors were identified: leukemia, number of catheters, history of catheterization, total parenteral nutrition, post-catheterization D-dimer, and post-catheterization fibrinogen. The p

SUBMITTER: Fu M 

PROVIDER: S-EPMC12152077 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature