Immune Response of Nile Tilapia (Oreochromis niloticus) Vaccinated With Diatom-Based Oral Vaccines Against Piscine Francisellosis.

ABSTRACT: Piscine francisellosis is a highly infectious and economically significant disease caused by Francisella orientalis in tilapia (Oreochromis spp.). There are currently no approved treatments or commercial vaccines for this disease in cultured fish. Injectable vaccines using diatoms as antigen expression vectors have demonstrated efficacy in tilapia models; however, no oral vaccine trials have been performed. We hypothesised that fusion proteins consisting of F. orientalis IglC and flagellin expressed in Thalassiosira pseudonana diatoms will act as self-adjuvanting antigen delivery systems to confer a protective immune response against F. orientalis in tilapia when administered as top-coated feed. Different treatments were immunised and subsequently provided with one or two boosters prior to

SUBMITTER: Meyer C 

PROVIDER: S-EPMC12152294 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature