The LATTICE Study: Design of a pilot feasibility randomized controlled trial of lithium to delay cognitive decline in mild cognitive impairment.

ABSTRACT:

Introduction

Interest has grown in lithium's neuroprotective properties in neurodegenerative illnesses. We discuss the design, rationale, and implementation of a pilot feasibility, double-blind, randomized placebo-controlled trial (RCT) examining whether lithium can delay cognitive decline in older adults with mild cognitive impairment (MCI).

Methods

The study launched in September 2017. The goal was to enroll 80 community-dwelling participants ≥ 60 years with MCI into an RCT in which they would participate for 2 years with baseline and follow-up assessment of cognition, brain imaging, and plasma-based biomarkers. Participants were randomized to lithium or placebo (1:1).

Results

We enrolled 80 MCI older adults into the RCT. Baseline characteristics included a mean (st

SUBMITTER: Gildengers AG 

PROVIDER: S-EPMC12152361 | biostudies-literature | 2025 Apr-Jun

REPOSITORIES: biostudies-literature