Epigenome-wide association study of cerebrospinal fluid-based biomarkers of Alzheimer's disease in cognitively normal individuals.

ABSTRACT:

Introduction

Cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are reliable predictors of future AD risk. We investigated whether pre-clinical changes in AD CSF biomarkers are reflected in blood DNA methylation (DNAm) levels in cognitively normal participants.

Methods

We profiled blood-based DNAm with the EPIC array in participants without a diagnosis of cognitive impairment in the Emory Healthy Brain Study (EHBS; N = 495), Alzheimer's Disease Neuroimaging Initiative (N = 122), and Parkinson's Progression Markers Initiative (N = 118) cohorts. Their CSF amyloid beta 42, total tau (t-tau), and phosphorylated tau181 levels were quantified using Elecsys immunoassays. We conducted epigenome-wide association studies to assess associations between DNAm and CSF biomar

SUBMITTER: Huls A 

PROVIDER: S-EPMC12152373 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature