GWAS links APOE to neuropsychiatric symptoms in mild cognitive impairment and dementia.

ABSTRACT:

Introduction

Neuropsychiatric symptoms in dementia (NPS) collectively refer to behavioral and psychological symptoms affecting individuals with mild cognitive impairment (MCI) or Alzheimer's disease or related dementia (ADRD). NPS are among the most troubling aspects of living with dementia but their treatments have limited efficacy. We aim to investigate genetic variants contributing to NPS to identify new therapeutic targets.

Methods

We performed a genome-wide association study (GWAS) for nine NPS domains measured by the Neuropsychiatric Symptom Inventory Questionnaire (NPI-Q) in 12,800 participants from Alzheimer's Disease Research Centers across the United States. We performed a replication analysis in two independent cohorts.

Results

We found genome-wide signific

SUBMITTER: Vattathil SM 

PROVIDER: S-EPMC12152374 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature