Health-related quality-of-life profile and clinical outcomes in first-line advanced renal cell carcinoma: a modeling analysis based on the CheckMate 9ER study.

ABSTRACT:

Background

For patients with advanced renal cell carcinoma, maintaining quality of life during treatment is a priority. The phase III CheckMate 9ER study demonstrated improved efficacy and health-related quality of life (HRQoL) outcomes with first-line cabozantinib plus nivolumab (CaboNivo) versus sunitinib (Sun) and underscored the need to improve understanding of the relationship between clinical efficacy and the patient treatment experience. In this work, we investigated the relationship between changes in HRQoL and clinical outcomes, as well as identifying symptom-based patient profiles that could predict disease course and clinical outcomes.

Materials and methods

This post hoc analysis of CheckMate 9ER used the patient-reported outcomes 19-item Functional Assessment of

SUBMITTER: Cella D 

PROVIDER: S-EPMC12152543 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature