Characterization of small nucleolar RNA retaining transcripts in human normal and cancer cells.

ABSTRACT: Small nucleolar RNAs are non-coding RNAs typically encoded within the introns of both protein-coding and non-coding genes. Interestingly, a significant fraction of snoRNA sequences is found as retained introns of specific mRNA isoforms expressed from their host gene. In the present study, we aimed to define the representation of small nucleolar RNA retaining transcripts across various human cell types and tissues including cancer. We found that these type of transcripts are widely represented in normal tissues and cancer-derived cell lines, appearing both in their full-length form and, frequently, in a shorter variant. We characterized the shortening position, which occurs at or very close to the retained small nucleolar RNA sequence at the 5' end. Interestingly, for some transcripts this

SUBMITTER: Rambaldelli G 

PROVIDER: S-EPMC12152556 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature