The impact of subunit type, alternative splicing, and auxiliary proteins on AMPA receptor trafficking.

ABSTRACT: AMPA receptors underlie fast excitatory synaptic transmission in the mammalian nervous system and are critical for the expression of synaptic plasticity. Four genes encode the AMPA receptor subunits, each subject to RNA editing and alternative splicing at multiple positions. In addition, each tetrameric AMPA receptor can harbor up to four auxiliary proteins of which there are multiple types. Subunit type, alternative splicing, and auxiliary proteins are all known to affect AMPA receptor gating and trafficking. However, determining which factors dominate AMPA receptor trafficking requires high-throughput assessment of trafficking across multiple conditions. Here, we deploy two such methods to assess the relative contribution of AMPA receptor subunit type (GluA1 versus GluA2), alternative sp

SUBMITTER: Couch T 

PROVIDER: S-EPMC12152890 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature