Coordinated subdomain movements of MlaC regulate ligand binding and transport.

ABSTRACT: MlaC is involved in the transportation of phospholipids between the inner and outer membranes of Gram-negative bacteria. This MlaC-mediated transport safeguards the outer membrane asymmetry thereby preserving its integrity and shielding effect against antibiotics, detergents, etc. MlaC is constituted by two domains, viz. nuclear transport factor 2-like and phospholipid-binding protein. These unique structural properties contribute to a novel ligand binding process and a diverse conformational landscape, which still remains a marginally investigated subject. In order to fill this knowledge gap, comprehensive molecular docking and simulation studies were performed. The docking experiments performed using these structures against different phospholipids reveal, for the first time, their prefe

SUBMITTER: Dutta A 

PROVIDER: S-EPMC12153054 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature