A dynamic histone-based chromatin regulatory toolkit underpins genome and developmental evolution in an invertebrate clade.

ABSTRACT:

Background

The dynamic addition and removal of posttranslational modifications on eukaryotic histones define regulatory regions that play a central role in genome and chromatin biology. However, our understanding of these regulatory mechanisms in animals is primarily based on a few model systems, preventing a general understanding of how histone-based regulation directs and promotes phenotypic variation during animal embryogenesis.

Results

Here, we apply a comprehensive multi-omics approach to dissect the histone-based regulatory complement in Annelida, one of the largest invertebrate clades. Annelids exhibit a conserved histone repertoire organized in clusters of dynamically regulated, hyperaccessible chromatin. However, unlike other animals with reduced genomes, the worm D

SUBMITTER: Martin-Zamora FM 

PROVIDER: S-EPMC12153100 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature