Causal relationships between alterations in shear stress-related genes and aneurysmal subarachnoid hemorrhage.

ABSTRACT:

Background

Current management of aneurysmal subarachnoid hemorrhage (aSAH) poses significant challenges, with emerging evidence implicating alterations in shear stress (SS) as critical in disease pathogenesis. However, the causal relationships and underlying molecular mechanisms remain elusive. This study aimed to elucidate the causal association of key SS-related genes with aSAH.

Methods

SS-related genes were curated from the GeneCards database and transcriptomic datasets responsive to SS conditions. Expression quantitative trait loci (eQTLs) associated with these genes were identified as instrumental variables. An integrative analysis of genome-wide association study data for aSAH with eQTLs was conducted using bidirectional two-sample Mendelian randomization (MR) to ident

SUBMITTER: Wu X 

PROVIDER: S-EPMC12153161 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature