MitoLEAF: mitochondrial DNA Lineage, Evolution, Annotation Framework.

ABSTRACT: The study of mitochondrial DNA (mtDNA) provides invaluable insights into genetic variation, human evolution, and disease mechanisms. However, maintaining a consistent and reliable classification system requires continuous updates. Since Phylotree updates ended in 2016, the accumulation of new haplogroup findings in individual studies has highlighted the critical need for a centralized resource to ensure consistent classifications. To address this gap, we present mitoLEAF, a collaborative, freely accessible, and academically driven repository for mitochondrial phylogenetic analyses. Unlike commercial alternatives that restrict access to their customers through subscription or purchase, mitoLEAF is openly accessible and replicable, ensuring transparency and scientific reproducibility. Hosted

SUBMITTER: Huber N 

PROVIDER: S-EPMC12153335 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature