VimR is a conserved master transcription regulator controlling virulence and metabolism in Pseudomonas.

ABSTRACT: Pseudomonas syringae, a highly destructive plant bacterial pathogen causing severe disease and significant yield losses in agriculture globally, has complex regulatory systems involving many transcriptional factors (TFs). Although the LysR-type transcriptional regulator (LTTR) protein family is a well-known group of TFs involved in diverse physiological functions, the roles of LTTRs in P. syringae remain largely unknown. In this study, we characterized a LysR-type TF, PSPPH4638, and designated it as the virulence and metabolism regulator VimR. Genome-wide identification of VimR using chromatin immunoprecipitation sequencing revealed 1032 binding sites in the genome, of which 85% were in intergenic regions. Transcriptomic analysis showed altered expression of 454 and 82 genes in response to

SUBMITTER: Chen F 

PROVIDER: S-EPMC12153348 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature