Morphological features and molecular mechanisms in peritoneal adhesions from patients with chronic abdominal postoperative pain.

ABSTRACT:

Background

Chronic abdominal pain affects 10-20% of all patients following abdominal surgery, with adhesions as a predominant cause. However, the biological mechanisms underlying adhesion-related pain are not fully elucidated. This study aimed to establish the morphological and molecular phenotype of adhesions in patients with and without chronic postoperative abdominal pain.

Methods

In this case-control study, biopsies of adhesions were obtained from patients with chronic postoperative abdominal pain (related to adhesions on cineMRI) and controls without pain, from two tertiary care and one secondary care hospital. Quantitative histological analysis of haematoxylin and eosin-stained sections was performed, while immunohistochemical (IHC) markers for nerve tissue (S100, calr

SUBMITTER: Toneman MK 

PROVIDER: S-EPMC12153383 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature