Gut Microbiota Variation in Aging Dogs with Osteoarthritis.

ABSTRACT: Gut microbiota composition plays a crucial role in host health and may be influenced by age and disease conditions. This study investigates the gut microbiota diversity of 175 dogs across three age groups (Junior (20-46 months, 43 dogs), Adult (47-92 months, 58 dogs), and Senior (93-168 months, 74 dogs), and examined the impact of osteoarthritis on microbial composition. Alpha diversity analysis using the Shannon and Chao1 indices were significant (p < 0.05) in Senior dogs Beta diversity analysis based on Bray-Curtis dissimilarity indices demonstrated substantial overlap in gut microbiota composition across age groups, with no significant clustering observed (p > 0.05). A second analysis compared the microbiota of 69 healthy dogs and 81 dogs affected by osteoarthritis (OA) in

SUBMITTER: Balouei F 

PROVIDER: S-EPMC12153520 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature