Spatiotemporal Dynamics of Pro-Inflammatory Mediator Expression in <i>Pelteobagrus vachelli</i> During Ichthyophthiriasis: A 40-Day Longitudinal Study of <i>IL-1β</i>, <i>IL-6</i>, and <i>SAA</i>.

ABSTRACT: Interleukin-1β (IL-1β), interleukin-6 (IL-6), and serum amyloid A (SAA) are key pro-inflammatory mediators in the regulation of immune responses. The hypothesis posits that their expression varies with the progression of Ichthyophthirius multifiliis (Ich) infection and may serve as predictors of disease outcome. To elucidate their spatiotemporal dynamics, the full-length CDS of IL-1β, IL-6, and SAA in Pelteobagrus vachelli were cloned, and then their mRNA levels were tracked from infection onset (day 0) to resolution (day 40) or mortality in seven tissues. Key findings revealed a surge in IL-1β expression in the kidney and SAA expression in the spleen at 5 days post-infection (dpi), coinciding with no visible symptoms. Significant SAA

SUBMITTER: He Y 

PROVIDER: S-EPMC12153630 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature