Network Pharmacology and Molecular Docking-Based Approach to Explore Potential Bioactive Compounds from <i>Kaempferia parviflora</i> on Chemokine Signaling Pathways in the Treatment of Psoriasis Disease.

ABSTRACT: Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation and dysregulated chemokine signaling. Kaempferia parviflora (KP) has long been valued for its medicinal properties; however, its specific role in psoriasis treatment remains unclear. This study investigates the anti-psoriatic potential of methoxyflavones derived from KP through an integrated approach combining network pharmacology, molecular docking, and experimental validation. A total of 232 target genes were identified as being associated with KP bioactive compounds, of which 64 overlapped with psoriasis-related genes implicated in chemokine signaling pathways. Molecular docking analyses revealed that key methoxyflavones interact with pivotal proteins such as protein kinase B (AKT1

SUBMITTER: Sakuludomkan C 

PROVIDER: S-EPMC12154073 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature