Identification of cross-stage, cross-species malaria CD8⁺ T cell antigens.

ABSTRACT: Malaria is one of the most prevalent parasitic diseases in the world. In 2023, 263 million malaria cases were estimated worldwide¹. Two species of Plasmodium, P. falciparum and P. vivax, cause most human malaria. Despite the licensing of two partially protective vaccines for P. falciparum, there is no vaccine capable of providing long-term control or elimination^2,3. A major limitation for vaccine development is the lack of validated T cell epitopes for either species that could be targeted by vaccines. P. vivax is the most widespread human malaria parasite and is the major species causing malaria in the Americas and Asia while P. falciparum is more prevalent in Africa¹. P. vivax exclusively infects reticulocytes in

SUBMITTER: Barbosa CRR 

PROVIDER: S-EPMC12154130 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature