Influence of HLA Class I and II Polymorphisms on COVID-19 Severity in a South Brazilian Population.

ABSTRACT: The high variability of human leukocyte antigen (HLA) genes results in each molecule having distinct antigenic peptide binding capacities, potentially influencing the immune response to SARS-CoV-2. This study aimed to investigate associations between HLA class I (A, B) and class II (DRB1) polymorphisms and COVID-19 severity in a South Brazilian population, and to evaluate the binding affinity of alleles to viral peptides. A cross-sectional study included 503 unvaccinated patients with RT-qPCR-confirmed COVID-19: 145 non-severe, 129 severe, and 229 critical. HLA typing was performed using PCR-SSO and Luminex™ technology. The DRB1*11 allelic group was significantly associated with protection against severe and critical cases, while D

SUBMITTER: Grava S 

PROVIDER: S-EPMC12154496 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature