Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease.

ABSTRACT: The network organization of the human brain dynamically reconfigures in response to changing environmental demands, an adaptive process that may be disrupted in a symptom-relevant manner across psychiatric illnesses. Here, in a transdiagnostic sample of participants with (n=134) and without (n=85) psychiatric diagnoses, functional connectomes from intrinsic (resting-state) and task-evoked fMRI were decomposed to identify constraints on brain network dynamics across six cognitive states. Hierarchical clustering of 110 clinical, behavioral, and cognitive measures identified participant-specific symptom profiles, revealing four core dimensions of functioning: internalizing, externalizing, cognitive, and social/reward. Brain network dynamics were flattened across cognitive states in individual

SUBMITTER: Cocuzza CV 

PROVIDER: S-EPMC12154617 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature