Reduced neuronal self-avoidance in mouse starburst amacrine cells with only one <i>Pcdhg</i> isoform.

ABSTRACT: The clustered protocadherins (cPcdhs) are a family of ~60 homophilic cell adhesion molecules expressed across three gene clusters (Pcdha, Pcdhb, and Pcdhg) with a variety of essential roles in the developing nervous system. Some of these roles rely on specific isoforms, while others are more consistent with a model of isoform redundancy or a requirement for diversity. The γ-Pcdhs (expressed from the Pcdhg gene cluster) are particularly important for neuronal self-avoidance in starburst amacrine cells in the mouse retina. Here, we used mouse mutants to test two of the C-type isoforms - γC4 and γC5 - and found that neither was required for normal self-avoidance. Conversely, when we analyzed a mutant with only γC4 intact, we found significant failures in self-avoid

SUBMITTER: McLeod CM 

PROVIDER: S-EPMC12154620 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature