SCOT+: A Comprehensive Software Suite for Single-Cell alignment Using Optimal Transport.

ABSTRACT:

Summary

New advances in single-cell multi-omics experiments have allowed biologists to examine how various biological factors regulate processes in concert on the cellular level. However, measuring multiple cellular features for a single cell can be quite resource-intensive or impossible with the current technology. By using optimal transport (OT) to align cells and features across disparate datasets produced by separate assays, Single Cell alignment using Optimal Transport+ (SCOT+), our unsupervised single-cell alignment software suite, allows biologists to align their data without the need for any correspondence. SCOT+ has a generic optimal transport solution that can be reduced to multiple different OT optimization procedures, each of which provide state-of-the-art single-cell a

SUBMITTER: Baker C 

PROVIDER: S-EPMC12154691 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature