Variation in structural location and amino acid conservation of functional sites in protein domain families.

ABSTRACT:

Background

The functional sites of a protein present important information for determining its cellular function and are fundamental in drug design. Accordingly, accurate methods for the prediction of functional sites are of immense value. Most available methods are based on a set of homologous sequences and structural or evolutionary information, and assume that functional sites are more conserved than the average. In the analysis presented here, we have investigated the conservation of location and type of amino acids at functional sites, and compared the behaviour of functional sites between different protein domains.

Results

Functional sites were extracted from experimentally determined structural complexes from the Protein Data Bank harbouring a conserved protein domain

SUBMITTER: Pils B 

PROVIDER: S-EPMC1215474 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature