An intermediate activation state primes Langerhans cell migration from the epidermis.

ABSTRACT: Langerhans cells (LCs) are a specialized subset of dendritic cells residing in the epidermis, where they form a dense network that functions as a frontline defense by detecting environmental antigens and sensing skin damage. Despite extensive research, many immunological and physiological aspects of LCs function remain poorly understood. In this study, we combined single-cell transcriptomic analysis and intravital imaging to reconstruct the activation trajectory of epidermal LCs and identified a distinct intermediate state that precedes their migration. We present a high-resolution single-cell transcriptomic dataset of over 22,000 high-quality epidermal LCs under both injured and homeostatic conditions. We found similar LCs responses to chemical and physical skin injuries. Our analysis def

SUBMITTER: Kiselev A 

PROVIDER: S-EPMC12154774 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature