The genomic legacy of selectively breeding rhesus macaques for HIV/AIDS-related research.

ABSTRACT:

Background

Rhesus macaques are the preferred non-human primate model for HIV/AIDS-related research. Specific major histocompatibility complex (MHC) haplotypes and genetic ancestry are linked to slow disease progression of Simian Immunodeficiency Virus (SIV) infections in macaques. To maximize their utility for HIV/AIDS research, the Southwest National Primate Research Center (SNPRC) has introduced targeted breeding strategies to reduce the prevalence of SIV-refractory MHC haplotypes and levels of admixture between Indian- and Chinese-origin macaques.

Results

We characterized the MHC region in SNPRC macaques by targeted deep sequencing of 1,458 animals born over a ten-year period. Following the implementation of MHC management strategies, the prevalence of SIV-refractory MHC

SUBMITTER: Lyke MM 

PROVIDER: S-EPMC12154786 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature