Intracellular interactions shape antiviral resistance outcomes in poliovirus via eco-evolutionary feedback.

ABSTRACT: Antiviral resistance evolution poses a major obstacle for controlling viral infections. A promising strategy is to target shared viral proteins that allow drug susceptible viruses to sensitize resistant ones during cellular coinfection, muting selection for resistance. Pocapavir, a poliovirus capsid inhibitor, employs this sociovirological strategy. While susceptible viruses significantly suppressed resistance in the presence of pocapavir in cell culture, a pocapavir clinical trial observed widespread resistance evolution and limited improvements to clearance times. To reconcile these findings, we present an intra-host eco-evolutionary model of poliovirus in the presence of pocapavir, which reproduces both the potent interference observed in vitro and the resistance emergence seen i

SUBMITTER: Robertson AJ 

PROVIDER: S-EPMC12154798 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature