High burden of premature ventricular contractions upregulates transcriptional markers of inflammation and promotes adverse cardiac remodeling linked to cardiomyopathy.

ABSTRACT: Premature ventricular contractions (PVCs) are the most prevalent ventricular arrhythmia in adults. High PVC burden can lead to left ventricular (LV) systolic dysfunction, eccentric hypertrophy, and an increased risk of heart failure (HF) and sudden cardiac death (SCD). Inadequate angiogenesis is a key determinant in the transition from adaptive to maladaptive cardiac hypertrophy and fibrosis is a risk factor for arrhythmia and SCD. To quantitatively assess structural remodeling and transcriptional alterations in PVC-induced cardiomyopathy (PVC-CM), animals were implanted with modified pacemakers to deliver bigeminal PVCs (200-220 ms coupling interval) for 12 weeks. Collagen deposition and interstitial ultrastructure of LV samples were analyzed using light and transmission ele

SUBMITTER: Medina-Contreras JML 

PROVIDER: S-EPMC12154820 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature