OGDHL regulates nucleotide metabolism, tumor growth, and neuroendocrine marker expression in prostate cancer.

ABSTRACT: Cells regularly adapt their metabolism in response to changes in their microenvironment or biosynthetic needs. Prostate cancer cells leverage this metabolic plasticity to evade therapies targeting the androgen receptor (AR) signaling pathway. For example, nucleotide metabolism plays a critical role in treatment-resistant prostate cancer by supporting DNA replication, DNA damage response and cell fate decisions. Identifying novel regulators of nucleotide metabolism in treatment-resistant cancer that are dispensable for the health of normal cells may lead to new therapeutic approaches less toxic than commonly used chemotherapies targeting nucleotide metabolism. We identify the metabolic enzyme Oxoglutarate Dehydrogenase-Like (OGDHL), named for its structural similarity to the tricarboxylic a

SUBMITTER: Bernard MJ 

PROVIDER: S-EPMC12154886 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature