Peripheral blood cell-type and sex-specific signatures of alcohol misuse revealed by single-cell transcriptomics.

ABSTRACT: Alcohol use disorder (AUD) is a complex condition with diverse molecular underpinnings. Chronic alcohol exposure is associated with alterations in both innate and adaptive immune cell populations that in turn contribute to AUD susceptibility and severity, suggesting a bidirectional gene-environment relationship. Yet, most clinical AUD studies of this system have relied on indirect measurement of immune function and/or assessment of only a small number of cell types or immune markers, approaches which cannot capture the immune system's inherent complexity and cellular heterogeneity. Therefore, in order to better characterize immune dysregulation in AUD, the goal of this study was to use single cell RNA sequencing (scRNA-seq) in peripheral blood mononuclear cells (PBMCs) to compare immune ce

SUBMITTER: Shetty AC 

PROVIDER: S-EPMC12154914 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature