Maternal obesity programs cardiac remodeling in offspring via epigenetic, metabolic, and immune dysregulations.

ABSTRACT: Maternal obesity during pregnancy significantly increases the offspring's risk of later-life cardiovascular disease. This study investigated cardiometabolic perturbations by utilizing a mouse model of maternal high-fat diet (HFD)-induced obesity that recapitulates metabolic abnormalities observed in humans. We report that offspring of HFD-fed mothers (Off-HFD) exhibit a progression of obesity, hypertension, dyslipidemia, and metabolic inflexibility when compared with offspring of regular diet-fed mothers (Off-RD). Deeper investigation of cardiac function further identified significant functional, metabolic, and immune perturbations in adult offspring of mothers on HFD. Specifically, Off-HFD mice presented progressing cardiac hypertrophy with reduced ejection fraction, increased accumulatio

SUBMITTER: Philips EA 

PROVIDER: S-EPMC12154923 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature