Genetic polymorphisms in DPF3 associated with risk of breast cancer and lymph node metastases.

ABSTRACT:

Background

Several studies have identified rare genetic variations responsible for many cases of familial breast cancer but their contribution to total breast cancer incidence is relatively small. More common genetic variations with low penetrance have been postulated to account for a higher proportion of the population risk of breast cancer.

Methods and results

In an effort to identify genes that influence non-familial breast cancer risk, we tested over 25,000 single nucleotide polymorphisms (SNPs) located within approximately 14,000 genes in a large-scale case-control study in 254 German women with breast cancer and 268 age-matched women without malignant disease. We identified a marker on chromosome 14q24.3-q31.1 that was marginally associated with breast cancer status (O

SUBMITTER: Hoyal CR 

PROVIDER: S-EPMC1215495 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature