Connectometry reveals differing associations of cortisol and PACAP with dorsal cingulum microstructure in posttraumatic stress.

ABSTRACT: Posttraumatic stress disorder (PTSD) has been associated with altered arousal regulation and dysfunction of the hypothalamic-pituitary-adrenal axis, including changes in circulating cortisol and pituitary adenylate cyclaseactivating polypeptide (PACAP). Both stress-related hormones affect extended amygdala to medial prefrontal cortex (mPFC) circuit functioning, but it is unclear whether they relate to white matter microstructure connecting these regions. We examined this question in 139 trauma-exposed adults (81 female; ages 19-54) who completed the Clinician-Administered PTSD Scale, a blood draw, and diffusion magnetic resonance imaging. White matter integrity was assessed in tracts connecting the extended amygdala to mPFC, including the uncinate fasciculus, frontal parahippocampal cingul

SUBMITTER: Granger SJ 

PROVIDER: S-EPMC12155003 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature