From Tool to Teammate: A Randomized Controlled Trial of Clinician-AI Collaborative Workflows for Diagnosis.

ABSTRACT: Early studies of large language models (LLMs) in clinical settings have largely treated artificial intelligence (AI) as a tool rather than an active collaborator. As LLMs now demonstrate expert-level diagnostic performance, the focus shifts from whether AI can offer valuable suggestions to how it can be effectively integrated into physicians' diagnostic workflows. We conducted a randomized controlled trial (n=70 clinicians) to evaluate the value of employing a custom GPT system designed to engage collaboratively with clinicians on diagnostic reasoning challenges. The collaborative design began with independent diagnostic assessments from both the clinician and the AI. These were then combined in an AI-generated synthesis that integrated the two perspectives, highlighting points of agreemen

SUBMITTER: Everett SS 

PROVIDER: S-EPMC12155023 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature