Serocalculator, an R package for estimating seroincidence from cross-sectional serological data.

ABSTRACT:

Motivation

Seroincidence-the rate of new infections in a population-is a key measure for understanding pathogen transmission dynamics and informing public health action. Estimating seroincidence from cross-sectional data is complicated by antibody waning, cross-reactivity, and individual heterogeneity in antibody responses.

Implementation

serocalculator is an open-source R package that uses a likelihood-based framework incorporating antibody decay models, biological variability, and measurement noise to estimate seroincidence rates from cross-sectional serological data.

General features

The package supports overall and stratified seroincidence estimation using single or multiple biomarkers. It requires three inputs: (1) a pre-estimated seroresponse model charac

SUBMITTER: Lai KW 

PROVIDER: S-EPMC12155044 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature