SLIT/ROBO Pathway and Prostate Cancer: Gene and Protein Expression and Their Prognostic Values.

ABSTRACT: Prostate cancer (PCa) is the second most common cancer and the second leading cause of cancer-related mortality among men. Gene expression analysis has been crucial in understanding tumor biology and providing disease progression markers. Cell surface glycoproteins and those in the extracellular matrix play significant roles in the PCa microenvironment by promoting migration, invasion, and metastasis. The molecular and histopathological heterogeneity of prostate tumors necessitates a new marker discovery to better stratify patients at risk for poor prognosis. In this study, our objectives were to investigate and characterize the localization and expression of SLIT/ROBO in PCa samples from transgenic mice and human tumor samples, aiming to identify novel prognostic markers and potential the

SUBMITTER: Santos NJ 

PROVIDER: S-EPMC12155087 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature