Day One Cell-Free DNA Levels as an Objective Prognostic Marker of Mortality in Major Burns Patients.

ABSTRACT:

Background

Cell-free DNA (cfDNA) released during tissue damage has attracted interest as a marker of patient outcomes. However, limited research has examined its predictive utility in thermally injured patients.

Methods

This study measured cfDNA concentrations across days 1, 3, 7, 14, and 28 post-burn in a total cohort of 98 adult patients with total body surface area (TBSA) burns ≥ 15% and healthy controls (HC). CfDNA concentrations in survivors (n = 79) versus non-survivors (n = 16) were compared and area under the receiver operating curve (AUROC) models generated to evaluate cfDNA as a predictor of mortality.

Results

Patient cfDNA levels were significantly elevated at all time points compared to HC. Positive correlations were identified between day 1 cfDNA concentr

SUBMITTER: Tullie S 

PROVIDER: S-EPMC12155140 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature