Elevated Mutation Burdens in Canadian Oat and Wheat Cultivars Released over the Past Century.

ABSTRACT: Modern high-yielding crop cultivars are known to have narrow genetic bases, making them vulnerable to biotic and abiotic stresses. However, little is known about the extent of deleterious genetic variants (or mutation burden) present in these cultivars. An attempt was made using RNA-Seq to screen genome-wide deleterious genetic variants in 141 oat and 142 wheat cultivars released through Canadian breeding programs over the past century. The screening identified 5726 and 3022 deleterious genetic variants across all 21 chromosomes of both the oat and wheat genomes, respectively. These deleterious variants were largely harbored in a few cultivars and were involved with diverse biological processes, cellular components, and molecular functions. More highly deleterious variants were predicted i

SUBMITTER: Fu YB 

PROVIDER: S-EPMC12155307 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature