Short-Chain Fatty Acids Are Potential Biomarkers of Immune Regulation in Diabetic Retinopathy.

ABSTRACT:

Purpose

Gut microbiota is involved in the pathophysiology of diabetes and its complications, yet the mechanistic link of short-chain fatty acids (SCFAs) produced by gut microbes in the pathogenesis of diabetic retinopathy (DR) remains unclear. The objective of the current study was to investigate the involvement of SCFAs in the development of DR.

Methods

We collected blood samples from 165 participants with diabetes mellitus and quantified plasma SCFAs using gas chromatography-mass spectrometry. Additionally, we explored proteomic profiles reflecting host responses to circulating SCFAs using the Olink platform. Using a streptozotocin-induced diabetic mouse model, we evaluated retinal morphological, pathological, and epigenetic changes following a 16-week acetate supplementat

SUBMITTER: Qin X 

PROVIDER: S-EPMC12155666 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature