Combined TNF-α and OX40L targeting as a new treatment option for hidradenitis suppurativa.

ABSTRACT:

Background

Chronic inflammatory conditions are among the leading causes of disability and mortality. Although therapies have been significantly improved with the introduction of target-specific biologics, many chronic inflammatory conditions can be only moderately controlled by inhibition of individual cytokines.

Objective

We sought to compare individual versus simultaneous blockade of TNF-α and OX40L in controlling inflammation.

Methods

Analysis was conducted of the murine xenograft graft-versus-host disease model, a novel cynomolgus monkey model of simultaneous T cell-dependent antibody response (TDAR) and delayed-type hypersensitivity (DTH) skin reaction, and samples of patients with hidradenitis suppurativa (HS).

Results

Compared with individual inhibition,

SUBMITTER: Leeuw T 

PROVIDER: S-EPMC12155757 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature