Association between hypoglycaemic drug de-intensification, mortality and hospital admission in older adults with type 2 diabetes: a cohort study emulating a target trial.

ABSTRACT:

Background

Hypoglycaemic drugs (sulfonylureas, glinides or insulins) are commonly prescribed for older adults with type 2 diabetes (T2D) but may carry risks of adverse events. Whether de-intensifying hypoglycaemic drugs is associated with clinical benefit in older adults remains unknown.

Objective

To evaluate the association between de-intensification of hypoglycaemic drugs and clinical outcomes in older adults with T2D.

Methods

Cohort study conducted with the target trial emulation approach, using data collected from 2000 French general practises between January 2010 and February 2019 (The Health Improvement Network-THIN database). Eligible participants were ≥75 years old, on stable hypoglycaemic drugs (no change in drug or dose) for at least 6 months, and had an HbA

SUBMITTER: Christiaens A 

PROVIDER: S-EPMC12156012 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature